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A glimpse at the aging eye
Extensive investigations have demonstrated that organismal aging is associated with tissue dysfunction in many organs. The eye is no exception to this rule. Under healthy conditions, the eye is designed like an advanced camera with the central role of translating light from the external world into a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515005/ https://www.ncbi.nlm.nih.gov/pubmed/28721262 http://dx.doi.org/10.1038/npjamd.2016.3 |
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author | Lin, Jonathan B Tsubota, Kazuo Apte, Rajendra S |
author_facet | Lin, Jonathan B Tsubota, Kazuo Apte, Rajendra S |
author_sort | Lin, Jonathan B |
collection | PubMed |
description | Extensive investigations have demonstrated that organismal aging is associated with tissue dysfunction in many organs. The eye is no exception to this rule. Under healthy conditions, the eye is designed like an advanced camera with the central role of translating light from the external world into a coherent neural signal that can be transmitted to the brain for processing into a precise visual image. This complex process requires precisely maintained machinery. At the front of the eye, the transparency of both the cornea and the lens are crucial to allow passage of photons to the light-sensitive portion of the eye. Similarly, the highly organized structure of the retina located at the back of the eye is indispensable to allow for effective signal transduction and efficient signal transmission. Aging affects ocular structures in various ways, and these sequelae have been well defined as distinct clinical entities. In many instances, aging leads to ocular tissue dysfunction and disease. Nonetheless, despite clear evidence that age-associated visual impairment has significant psychosocial consequences, current treatment paradigms for many of these conditions are inadequate. In addition, strategies to decelerate or reverse age-associated deterioration in ocular function are still in their infancy. This review focuses on the cellular and molecular pathophysiology of the aging eye. Ultimately, we hope that a refined understanding of the aging eye can guide targeted therapies against cellular aging and disease. |
format | Online Article Text |
id | pubmed-5515005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55150052017-07-18 A glimpse at the aging eye Lin, Jonathan B Tsubota, Kazuo Apte, Rajendra S NPJ Aging Mech Dis Review Article Extensive investigations have demonstrated that organismal aging is associated with tissue dysfunction in many organs. The eye is no exception to this rule. Under healthy conditions, the eye is designed like an advanced camera with the central role of translating light from the external world into a coherent neural signal that can be transmitted to the brain for processing into a precise visual image. This complex process requires precisely maintained machinery. At the front of the eye, the transparency of both the cornea and the lens are crucial to allow passage of photons to the light-sensitive portion of the eye. Similarly, the highly organized structure of the retina located at the back of the eye is indispensable to allow for effective signal transduction and efficient signal transmission. Aging affects ocular structures in various ways, and these sequelae have been well defined as distinct clinical entities. In many instances, aging leads to ocular tissue dysfunction and disease. Nonetheless, despite clear evidence that age-associated visual impairment has significant psychosocial consequences, current treatment paradigms for many of these conditions are inadequate. In addition, strategies to decelerate or reverse age-associated deterioration in ocular function are still in their infancy. This review focuses on the cellular and molecular pathophysiology of the aging eye. Ultimately, we hope that a refined understanding of the aging eye can guide targeted therapies against cellular aging and disease. Nature Publishing Group 2016-03-10 /pmc/articles/PMC5515005/ /pubmed/28721262 http://dx.doi.org/10.1038/npjamd.2016.3 Text en Copyright © 2016 Japanese Society of Anti-Aging Medicine/Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Review Article Lin, Jonathan B Tsubota, Kazuo Apte, Rajendra S A glimpse at the aging eye |
title | A glimpse at the aging eye |
title_full | A glimpse at the aging eye |
title_fullStr | A glimpse at the aging eye |
title_full_unstemmed | A glimpse at the aging eye |
title_short | A glimpse at the aging eye |
title_sort | glimpse at the aging eye |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515005/ https://www.ncbi.nlm.nih.gov/pubmed/28721262 http://dx.doi.org/10.1038/npjamd.2016.3 |
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