Sequence-specific DNA binding by MYC/MAX to low-affinity non-E-box motifs

The MYC oncoprotein regulates transcription of a large fraction of the genome as an obligatory heterodimer with the transcription factor MAX. The MYC:MAX heterodimer and MAX:MAX homodimer (hereafter MYC/MAX) bind Enhancer box (E-box) DNA elements (CANNTG) and have the greatest affinity for the canon...

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Detalles Bibliográficos
Autores principales: Allevato, Michael, Bolotin, Eugene, Grossman, Mark, Mane-Padros, Daniel, Sladek, Frances M., Martinez, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515408/
https://www.ncbi.nlm.nih.gov/pubmed/28719624
http://dx.doi.org/10.1371/journal.pone.0180147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515408/
https://www.ncbi.nlm.nih.gov/pubmed/28719624
http://dx.doi.org/10.1371/journal.pone.0180147

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