Isolation of putative stem cells present in human adult olfactory mucosa

The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans make...

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Autores principales: Tanos, Tamara, Saibene, Alberto Maria, Pipolo, Carlotta, Battaglia, Paolo, Felisati, Giovanni, Rubio, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515430/
https://www.ncbi.nlm.nih.gov/pubmed/28719644
http://dx.doi.org/10.1371/journal.pone.0181151
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author Tanos, Tamara
Saibene, Alberto Maria
Pipolo, Carlotta
Battaglia, Paolo
Felisati, Giovanni
Rubio, Alicia
author_facet Tanos, Tamara
Saibene, Alberto Maria
Pipolo, Carlotta
Battaglia, Paolo
Felisati, Giovanni
Rubio, Alicia
author_sort Tanos, Tamara
collection PubMed
description The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.
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spelling pubmed-55154302017-08-07 Isolation of putative stem cells present in human adult olfactory mucosa Tanos, Tamara Saibene, Alberto Maria Pipolo, Carlotta Battaglia, Paolo Felisati, Giovanni Rubio, Alicia PLoS One Research Article The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling. Public Library of Science 2017-07-18 /pmc/articles/PMC5515430/ /pubmed/28719644 http://dx.doi.org/10.1371/journal.pone.0181151 Text en © 2017 Tanos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tanos, Tamara
Saibene, Alberto Maria
Pipolo, Carlotta
Battaglia, Paolo
Felisati, Giovanni
Rubio, Alicia
Isolation of putative stem cells present in human adult olfactory mucosa
title Isolation of putative stem cells present in human adult olfactory mucosa
title_full Isolation of putative stem cells present in human adult olfactory mucosa
title_fullStr Isolation of putative stem cells present in human adult olfactory mucosa
title_full_unstemmed Isolation of putative stem cells present in human adult olfactory mucosa
title_short Isolation of putative stem cells present in human adult olfactory mucosa
title_sort isolation of putative stem cells present in human adult olfactory mucosa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515430/
https://www.ncbi.nlm.nih.gov/pubmed/28719644
http://dx.doi.org/10.1371/journal.pone.0181151
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