The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states

Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na(+)-Cl(-) Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered...

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Detalles Bibliográficos
Autores principales: Alshahrani, Saeed, Rapoport, Robert M., Zahedi, Kamyar, Jiang, Min, Nieman, Michelle, Barone, Sharon, Meredith, Andrea L., Lorenz, John N., Rubinstein, Jack, Soleimani, Manoocher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515454/
https://www.ncbi.nlm.nih.gov/pubmed/28719636
http://dx.doi.org/10.1371/journal.pone.0181376

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