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Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice

AIMS: The Mice Drawer System (MDS) Tissue Sharing program was the longest rodent space mission ever performed. It provided 20 research teams with organs and tissues collected from mice having spent 3 months on the International Space Station (ISS). Our participation to this experiment aimed at inves...

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Autores principales: Neutelings, Thibaut, Nusgens, Betty V, Liu, Yi, Tavella, Sara, Ruggiu, Alessandra, Cancedda, Ranieri, Gabriel, Maude, Colige, Alain, Lambert, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515501/
https://www.ncbi.nlm.nih.gov/pubmed/28725708
http://dx.doi.org/10.1038/npjmgrav.2015.2
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author Neutelings, Thibaut
Nusgens, Betty V
Liu, Yi
Tavella, Sara
Ruggiu, Alessandra
Cancedda, Ranieri
Gabriel, Maude
Colige, Alain
Lambert, Charles
author_facet Neutelings, Thibaut
Nusgens, Betty V
Liu, Yi
Tavella, Sara
Ruggiu, Alessandra
Cancedda, Ranieri
Gabriel, Maude
Colige, Alain
Lambert, Charles
author_sort Neutelings, Thibaut
collection PubMed
description AIMS: The Mice Drawer System (MDS) Tissue Sharing program was the longest rodent space mission ever performed. It provided 20 research teams with organs and tissues collected from mice having spent 3 months on the International Space Station (ISS). Our participation to this experiment aimed at investigating the impact of such prolonged exposure to extreme space conditions on mouse skin physiology. METHODS: Mice were maintained in the MDS for 91 days aboard ISS (space group (S)). Skin specimens were collected shortly after landing for morphometric, biochemical, and transcriptomic analyses. An exact replicate of the experiment in the MDS was performed on ground (ground group (G)). RESULTS: A significant reduction of dermal thickness (−15%, P=0.05) was observed in S mice accompanied by an increased newly synthetized procollagen (+42%, P=0.03), likely reflecting an increased collagen turnover. Transcriptomic data suggested that the dermal atrophy might be related to an early degradation of defective newly formed procollagen molecules. Interestingly, numerous hair follicles in growing anagen phase were observed in the three S mice, validated by a high expression of specific hair follicles genes, while only one mouse in the G controls showed growing hairs. By microarray analysis of whole thickness skin, we observed a significant modulation of 434 genes in S versus G mice. A large proportion of the upregulated transcripts encoded proteins related to striated muscle homeostasis. CONCLUSIONS: These data suggest that a prolonged exposure to space conditions may induce skin atrophy, deregulate hair follicle cycle, and markedly affect the transcriptomic repertoire of the cutaneous striated muscle panniculus carnosus.
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spelling pubmed-55155012017-07-19 Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice Neutelings, Thibaut Nusgens, Betty V Liu, Yi Tavella, Sara Ruggiu, Alessandra Cancedda, Ranieri Gabriel, Maude Colige, Alain Lambert, Charles NPJ Microgravity Article AIMS: The Mice Drawer System (MDS) Tissue Sharing program was the longest rodent space mission ever performed. It provided 20 research teams with organs and tissues collected from mice having spent 3 months on the International Space Station (ISS). Our participation to this experiment aimed at investigating the impact of such prolonged exposure to extreme space conditions on mouse skin physiology. METHODS: Mice were maintained in the MDS for 91 days aboard ISS (space group (S)). Skin specimens were collected shortly after landing for morphometric, biochemical, and transcriptomic analyses. An exact replicate of the experiment in the MDS was performed on ground (ground group (G)). RESULTS: A significant reduction of dermal thickness (−15%, P=0.05) was observed in S mice accompanied by an increased newly synthetized procollagen (+42%, P=0.03), likely reflecting an increased collagen turnover. Transcriptomic data suggested that the dermal atrophy might be related to an early degradation of defective newly formed procollagen molecules. Interestingly, numerous hair follicles in growing anagen phase were observed in the three S mice, validated by a high expression of specific hair follicles genes, while only one mouse in the G controls showed growing hairs. By microarray analysis of whole thickness skin, we observed a significant modulation of 434 genes in S versus G mice. A large proportion of the upregulated transcripts encoded proteins related to striated muscle homeostasis. CONCLUSIONS: These data suggest that a prolonged exposure to space conditions may induce skin atrophy, deregulate hair follicle cycle, and markedly affect the transcriptomic repertoire of the cutaneous striated muscle panniculus carnosus. Nature Publishing Group 2015-05-27 /pmc/articles/PMC5515501/ /pubmed/28725708 http://dx.doi.org/10.1038/npjmgrav.2015.2 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Neutelings, Thibaut
Nusgens, Betty V
Liu, Yi
Tavella, Sara
Ruggiu, Alessandra
Cancedda, Ranieri
Gabriel, Maude
Colige, Alain
Lambert, Charles
Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title_full Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title_fullStr Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title_full_unstemmed Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title_short Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
title_sort skin physiology in microgravity: a 3-month stay aboard iss induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515501/
https://www.ncbi.nlm.nih.gov/pubmed/28725708
http://dx.doi.org/10.1038/npjmgrav.2015.2
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