Longevity is impacted by growth hormone action during early postnatal period

Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. St...

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Autores principales: Sun, Liou Y, Fang, Yimin, Patki, Amit, Koopman, Jacob JE, Allison, David B, Hill, Cristal M, Masternak, Michal M, Darcy, Justin, Wang, Jian, McFadden, Samuel, Bartke, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515575/
https://www.ncbi.nlm.nih.gov/pubmed/28675141
http://dx.doi.org/10.7554/eLife.24059
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author Sun, Liou Y
Fang, Yimin
Patki, Amit
Koopman, Jacob JE
Allison, David B
Hill, Cristal M
Masternak, Michal M
Darcy, Justin
Wang, Jian
McFadden, Samuel
Bartke, Andrzej
author_facet Sun, Liou Y
Fang, Yimin
Patki, Amit
Koopman, Jacob JE
Allison, David B
Hill, Cristal M
Masternak, Michal M
Darcy, Justin
Wang, Jian
McFadden, Samuel
Bartke, Andrzej
author_sort Sun, Liou Y
collection PubMed
description Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. Studies in a separate cohort of Ames dwarf mice show that this short period of the GH exposure during early development produces persistent phenotypic, metabolic and molecular changes that are evident in late adult life. These effects may represent mechanisms responsible for reduced longevity of dwarf mice exposed to GH treatment early in life. Our data suggest that developmental programming of aging importantly contributes to (and perhaps explains) the well documented developmental origins of adult disease. DOI: http://dx.doi.org/10.7554/eLife.24059.001
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spelling pubmed-55155752017-07-19 Longevity is impacted by growth hormone action during early postnatal period Sun, Liou Y Fang, Yimin Patki, Amit Koopman, Jacob JE Allison, David B Hill, Cristal M Masternak, Michal M Darcy, Justin Wang, Jian McFadden, Samuel Bartke, Andrzej eLife Developmental Biology and Stem Cells Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. Studies in a separate cohort of Ames dwarf mice show that this short period of the GH exposure during early development produces persistent phenotypic, metabolic and molecular changes that are evident in late adult life. These effects may represent mechanisms responsible for reduced longevity of dwarf mice exposed to GH treatment early in life. Our data suggest that developmental programming of aging importantly contributes to (and perhaps explains) the well documented developmental origins of adult disease. DOI: http://dx.doi.org/10.7554/eLife.24059.001 eLife Sciences Publications, Ltd 2017-07-04 /pmc/articles/PMC5515575/ /pubmed/28675141 http://dx.doi.org/10.7554/eLife.24059 Text en © 2017, Sun et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology and Stem Cells
Sun, Liou Y
Fang, Yimin
Patki, Amit
Koopman, Jacob JE
Allison, David B
Hill, Cristal M
Masternak, Michal M
Darcy, Justin
Wang, Jian
McFadden, Samuel
Bartke, Andrzej
Longevity is impacted by growth hormone action during early postnatal period
title Longevity is impacted by growth hormone action during early postnatal period
title_full Longevity is impacted by growth hormone action during early postnatal period
title_fullStr Longevity is impacted by growth hormone action during early postnatal period
title_full_unstemmed Longevity is impacted by growth hormone action during early postnatal period
title_short Longevity is impacted by growth hormone action during early postnatal period
title_sort longevity is impacted by growth hormone action during early postnatal period
topic Developmental Biology and Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515575/
https://www.ncbi.nlm.nih.gov/pubmed/28675141
http://dx.doi.org/10.7554/eLife.24059
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