Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial

OBJECTIVE: The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative phosphorylation, altering metabolism. Though the mechanism is unclear, epidemiologic studies show an association between metfor...

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Detalles Bibliográficos
Autores principales: Curry, Joseph, Johnson, Jennifer, Tassone, Patrick, Vidal, Marina Domingo, Menezes, Diana Whitaker, Sprandio, John, Mollaee, Mehri, Cotzia, Paolo, Birbe, Ruth, Lin, Zhao, Gill, Kurren, Duddy, Elizabeth, Zhan, Tingting, Leiby, Benjamin, Reyzer, Michelle, Cognetti, David, Luginbuhl, Adam, Tuluc, Madalina, Martinez‐Outschoorn, Ubaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Head and Neck
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515672/
https://www.ncbi.nlm.nih.gov/pubmed/28185288
http://dx.doi.org/10.1002/lary.26489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515672/
https://www.ncbi.nlm.nih.gov/pubmed/28185288
http://dx.doi.org/10.1002/lary.26489

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