Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

The threat of a major coronavirus pandemic urges the development of strategies to combat these pathogens. Human coronavirus NL63 (HCoV-NL63) is an α-coronavirus that can cause severe lower-respiratory-tract infections requiring hospitalization. We report here the 3.4-Å-resolution cryo-EM reconstruct...

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Detalles Bibliográficos
Autores principales: Walls, Alexandra C, Tortorici, M Alejandra, Frenz, Brandon, Snijder, Joost, Li, Wentao, Rey, Félix A, DiMaio, Frank, Bosch, Berend-Jan, Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515730/
https://www.ncbi.nlm.nih.gov/pubmed/27617430
http://dx.doi.org/10.1038/nsmb.3293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515730/
https://www.ncbi.nlm.nih.gov/pubmed/27617430
http://dx.doi.org/10.1038/nsmb.3293

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