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Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515848/ https://www.ncbi.nlm.nih.gov/pubmed/28720904 http://dx.doi.org/10.1038/s41598-017-06408-4 |
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author | Kim, Wha Young Cho, Bo Ram Kwak, Myung Ji Kim, Jeong-Hoon |
author_facet | Kim, Wha Young Cho, Bo Ram Kwak, Myung Ji Kim, Jeong-Hoon |
author_sort | Kim, Wha Young |
collection | PubMed |
description | Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process. |
format | Online Article Text |
id | pubmed-5515848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55158482017-07-19 Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task Kim, Wha Young Cho, Bo Ram Kwak, Myung Ji Kim, Jeong-Hoon Sci Rep Article Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process. Nature Publishing Group UK 2017-07-18 /pmc/articles/PMC5515848/ /pubmed/28720904 http://dx.doi.org/10.1038/s41598-017-06408-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Wha Young Cho, Bo Ram Kwak, Myung Ji Kim, Jeong-Hoon Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title | Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title_full | Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title_fullStr | Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title_full_unstemmed | Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title_short | Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
title_sort | interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515848/ https://www.ncbi.nlm.nih.gov/pubmed/28720904 http://dx.doi.org/10.1038/s41598-017-06408-4 |
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