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Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task

Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference...

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Autores principales: Kim, Wha Young, Cho, Bo Ram, Kwak, Myung Ji, Kim, Jeong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515848/
https://www.ncbi.nlm.nih.gov/pubmed/28720904
http://dx.doi.org/10.1038/s41598-017-06408-4
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author Kim, Wha Young
Cho, Bo Ram
Kwak, Myung Ji
Kim, Jeong-Hoon
author_facet Kim, Wha Young
Cho, Bo Ram
Kwak, Myung Ji
Kim, Jeong-Hoon
author_sort Kim, Wha Young
collection PubMed
description Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process.
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spelling pubmed-55158482017-07-19 Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task Kim, Wha Young Cho, Bo Ram Kwak, Myung Ji Kim, Jeong-Hoon Sci Rep Article Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules. Then, the rats were allowed to freely choose from 4 different light signals. Once animals showed a stabilized pattern of preference (risk-averse or risk-seeking), they were injected with saline or cocaine (a single injection per day for 7 days) followed by 2 weeks of withdrawal. Then, their preference of choice was re-tested in the touch screen chamber while they were cocaine challenged. All rats significantly changed their preference toward more risky choices when they were exposed to and challenged with cocaine, except those in the risk-averse/isolated housing group. These results indicate that the pre-existing trait toward risk and the housing condition interact to affect the quality of decision-making, and cocaine may help to aggravate this process. Nature Publishing Group UK 2017-07-18 /pmc/articles/PMC5515848/ /pubmed/28720904 http://dx.doi.org/10.1038/s41598-017-06408-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Wha Young
Cho, Bo Ram
Kwak, Myung Ji
Kim, Jeong-Hoon
Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_full Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_fullStr Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_full_unstemmed Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_short Interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
title_sort interaction between trait and housing condition produces differential decision-making toward risk choice in a rat gambling task
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515848/
https://www.ncbi.nlm.nih.gov/pubmed/28720904
http://dx.doi.org/10.1038/s41598-017-06408-4
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