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Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity
OBJECTIVES: We evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD). METHODS: We used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515862/ https://www.ncbi.nlm.nih.gov/pubmed/28769863 http://dx.doi.org/10.3389/fneur.2017.00327 |
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author | Valdés Hernández, Maria del C. González-Castro, Victor Chappell, Francesca M. Sakka, Eleni Makin, Stephen Armitage, Paul A. Nailon, William H. Wardlaw, Joanna M. |
author_facet | Valdés Hernández, Maria del C. González-Castro, Victor Chappell, Francesca M. Sakka, Eleni Makin, Stephen Armitage, Paul A. Nailon, William H. Wardlaw, Joanna M. |
author_sort | Valdés Hernández, Maria del C. |
collection | PubMed |
description | OBJECTIVES: We evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD). METHODS: We used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmented tissues, white matter hyperintensities (WMH) and applied validated visual scores. We measured textural features in all tissues pre- and post-contrast and used ANCOVA to evaluate the effect of SVD indicators on the pre-/post-contrast change, Kruskal–Wallis for significance between patient groups and linear mixed models for pre-/post-contrast variations in cerebrospinal fluid (CSF) with Fazekas scores. RESULTS: Textural “homogeneity” increase in normal tissues with higher presence of SVD indicators was consistently more overt than in abnormal tissues. Textural “homogeneity” increased with age, basal ganglia perivascular spaces scores (p < 0.01) and SVD scores (p < 0.05) and was significantly higher in hypertensive patients (p < 0.002) and lacunar stroke (p = 0.04). Hypertension (74% patients), WMH load (median = 1.5 ± 1.6% of intracranial volume), and age (mean = 65.6 years, SD = 11.3) predicted the pre/post-contrast change in normal white matter, WMH, and index stroke lesion. CSF signal increased with increasing SVD post-contrast. CONCLUSION: A consistent general pattern of increasing textural “homogeneity” with increasing SVD and post-contrast change in CSF with increasing WMH suggest that texture analysis may be useful for the study of BBB integrity. |
format | Online Article Text |
id | pubmed-5515862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55158622017-08-02 Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity Valdés Hernández, Maria del C. González-Castro, Victor Chappell, Francesca M. Sakka, Eleni Makin, Stephen Armitage, Paul A. Nailon, William H. Wardlaw, Joanna M. Front Neurol Neuroscience OBJECTIVES: We evaluate the alternative use of texture analysis for evaluating the role of blood–brain barrier (BBB) in small vessel disease (SVD). METHODS: We used brain magnetic resonance imaging from 204 stroke patients, acquired before and 20 min after intravenous gadolinium administration. We segmented tissues, white matter hyperintensities (WMH) and applied validated visual scores. We measured textural features in all tissues pre- and post-contrast and used ANCOVA to evaluate the effect of SVD indicators on the pre-/post-contrast change, Kruskal–Wallis for significance between patient groups and linear mixed models for pre-/post-contrast variations in cerebrospinal fluid (CSF) with Fazekas scores. RESULTS: Textural “homogeneity” increase in normal tissues with higher presence of SVD indicators was consistently more overt than in abnormal tissues. Textural “homogeneity” increased with age, basal ganglia perivascular spaces scores (p < 0.01) and SVD scores (p < 0.05) and was significantly higher in hypertensive patients (p < 0.002) and lacunar stroke (p = 0.04). Hypertension (74% patients), WMH load (median = 1.5 ± 1.6% of intracranial volume), and age (mean = 65.6 years, SD = 11.3) predicted the pre/post-contrast change in normal white matter, WMH, and index stroke lesion. CSF signal increased with increasing SVD post-contrast. CONCLUSION: A consistent general pattern of increasing textural “homogeneity” with increasing SVD and post-contrast change in CSF with increasing WMH suggest that texture analysis may be useful for the study of BBB integrity. Frontiers Media S.A. 2017-07-19 /pmc/articles/PMC5515862/ /pubmed/28769863 http://dx.doi.org/10.3389/fneur.2017.00327 Text en Copyright © 2017 Valdés Hernández, González-Castro, Chappell, Sakka, Makin, Armitage, Nailon and Wardlaw. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Valdés Hernández, Maria del C. González-Castro, Victor Chappell, Francesca M. Sakka, Eleni Makin, Stephen Armitage, Paul A. Nailon, William H. Wardlaw, Joanna M. Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title_full | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title_fullStr | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title_full_unstemmed | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title_short | Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity |
title_sort | application of texture analysis to study small vessel disease and blood–brain barrier integrity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515862/ https://www.ncbi.nlm.nih.gov/pubmed/28769863 http://dx.doi.org/10.3389/fneur.2017.00327 |
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