Cargando…

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

BACKGROUND: There is a continued need to develop more effective cancer immunotherapy strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum of cell proteins represent a novel platform for delivering high levels of antigen in conjunction with costimulatory mol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morse, Michael A, Garst, Jennifer, Osada, Takuya, Khan, Shubi, Hobeika, Amy, Clay, Timothy M, Valente, Nancy, Shreeniwas, Revati, Sutton, Mary Ann, Delcayre, Alain, Hsu, Di-Hwei, Le Pecq, Jean-Bernard, Lyerly, H Kim
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551593/ https://www.ncbi.nlm.nih.gov/pubmed/15723705 http://dx.doi.org/10.1186/1479-5876-3-9

Ejemplares similares

Dexosomes as a cell-free vaccine for cancer immunotherapy
por: Nikfarjam, Sepideh, et al.
Publicado: (2020)

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
por: Osada, T, et al.
Publicado: (2010)

Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion
por: Hamilton, Erika, et al.
Publicado: (2013)

Phase I study of alphaviral vector (AVX701) in colorectal cancer patients: comparison of immune responses in stage III and stage IV patients
por: Morse, Michael A, et al.
Publicado: (2015)

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial
por: Mutlu, Esra Cansever, et al.
Publicado: (2020)

Phase I clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion
por: Hamilton, Erika, et al.
Publicado: (2012)

Exosome nanovesicles displaying G protein-coupled receptors for drug discovery
por: Estelles, Angeles, et al.
Publicado: (2007)

Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2
por: Morse, Michael A, et al.
Publicado: (2007)

Different In Vitro-Generated MUTZ-3-Derived Dendritic Cell Types Secrete Dexosomes with Distinct Phenotypes and Antigen Presentation Potencies
por: Sakamoto, Takuya, et al.
Publicado: (2022)

Clinical trials of self-replicating RNA-based cancer vaccines
por: Morse, Michael A., et al.
Publicado: (2023)

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers
por: Osada, Takuya, et al.
Publicado: (2018)

Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio
por: Crosby, Erika J, et al.
Publicado: (2020)

Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells
por: Ren, Xiu-Rong, et al.
Publicado: (2012)

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers
por: Kaneko, Kensuke, et al.
Publicado: (2022)

Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy
por: Yang, Duo, et al.
Publicado: (2021)

Predictive significance of T cell subset changes during ex vivo generation of adoptive cellular therapy products for the treatment of advanced non-small cell lung cancer
por: Huang, Lefu, et al.
Publicado: (2019)

Optimization of vaccine responses with an E1, E2b, E3 deleted Ad5 vector circumvents pre-existing anti-vector immunity
por: Osada, Takuya, et al.
Publicado: (2009)

Histological and Molecular Evaluation of Patient-Derived Colorectal Cancer Explants
por: Uronis, Joshua M., et al.
Publicado: (2012)

CBPR: AN EFFECTIVE APPROACH TO RECRUIT AND RETAIN MINORITY OLDER REFUGEE ADULTS IN COMMUNITY-BASED RESEARCH
por: Shreeniwas, Sudha
Publicado: (2022)

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth
por: Ren, Xiu-Rong, et al.
Publicado: (2015)

Self-replicating messenger RNA based cancer immunotherapy
por: Lyerly, Herbert Kim
Publicado: (2023)

Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy
por: Mandl, Stefanie J, et al.
Publicado: (2014)

Poxvirus immunotherapies in combination with immune checkpoint inhibitors synergize to eliminate tumors in a mouse tumor model
por: Foy, Susan P, et al.
Publicado: (2013)

A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity
por: Kaneko, Kensuke, et al.
Publicado: (2022)

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study
por: Osada, Takuya, et al.
Publicado: (2022)

Targeting of phosphatidylserine by monoclonal antibodies augments the activity of paclitaxel and anti-PD1/PD-L1 therapy in the murine breast model E0771
por: Gray, Michael, et al.
Publicado: (2015)

Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
por: Tsai, Hwei-Fang, et al.
Publicado: (2017)

The prognostic value of peripheral CD4(+)CD25(+) T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion
por: Song, Qing-Kun, et al.
Publicado: (2015)

Immunotherapy with MVA-BN(®)-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells
por: Mandl, Stefanie J., et al.
Publicado: (2011)

Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells
por: Foy, Susan P., et al.
Publicado: (2016)

Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression
por: Hwang, Bin-Jin, et al.
Publicado: (2022)

Non-infectious complications of continuous ambulatory peritoneal dialysis and their impact on technique survival
por: Prakash, J., et al.
Publicado: (2011)

Topotecan: An evolving option in the treatment of relapsed small cell lung cancer
por: Garst, Jennifer
Publicado: (2007)

Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma
por: Rebbeck, Clare A., et al.
Publicado: (2022)

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
por: Escudier, Bernard, et al.
Publicado: (2005)

Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors
por: Kaneko, Kensuke, et al.
Publicado: (2020)

Investigation of HIFU-induced anti-tumor immunity in a murine tumor model
por: Hu, Zhenlin, et al.
Publicado: (2007)

Inglés como medio de comunicación en las ciencias, la tecnología y las humanidades
por: Garst, Thomas E
Publicado: (1976)

Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity
por: Abe, Shinya, et al.
Publicado: (2022)

Physiological aspects of the determination of comprehensive arterial inflows in the lower abdomen assessed by Doppler ultrasound
por: Osada, Takuya
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_h2miak08vdsre7s7iktm1p73u5