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Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibrobl...

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Detalles Bibliográficos
Autores principales:	Ansorge, Michael, Sapudom, Jiranuwat, Chkolnikov, Marina, Wilde, Martin, Anderegg, Ulf, Möller, Stephanie, Schnabelrauch, Matthias, Pompe, Tilo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515936/ https://www.ncbi.nlm.nih.gov/pubmed/28720779 http://dx.doi.org/10.1038/s41598-017-05912-x

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