Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity are poorly understood. Here, the 31 KIs were test...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Salminen, Alec, Yang, Xi, Luo, Yong, Wu, Qiangen, White, Matthew, Greenhaw, James, Ren, Lijun, Bryant, Matthew, Salminen, William, Papoian, Thomas, Mattes, William, Shi, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515969/
https://www.ncbi.nlm.nih.gov/pubmed/28032146
http://dx.doi.org/10.1007/s00204-016-1918-1

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