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Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories
Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in memory form...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516032/ https://www.ncbi.nlm.nih.gov/pubmed/28720795 http://dx.doi.org/10.1038/s41598-017-05929-2 |
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author | Park, Youngjin Choi, Woochul Paik, Se-Bum |
author_facet | Park, Youngjin Choi, Woochul Paik, Se-Bum |
author_sort | Park, Youngjin |
collection | PubMed |
description | Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in memory formation still remain elusive. Here, we show that the symmetry of the learning rate profile in STDP is crucial to determining the character of stored memory. Using computer simulations, we found that an asymmetric learning rate generates flexible memory that is volatile and easily overwritten by newly appended information. Moreover, a symmetric learning rate generates stable memory that can coexist with newly appended information. In addition, by combining these two conditions, we could realize a hybrid memory type that operates in a way intermediate between stable and flexible memory. Our results demonstrate that various attributes of memory functions may originate from differences in the synaptic stability. |
format | Online Article Text |
id | pubmed-5516032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55160322017-07-19 Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories Park, Youngjin Choi, Woochul Paik, Se-Bum Sci Rep Article Spike-timing-dependent plasticity (STDP) is considered critical to learning and memory functions in the human brain. Across various types of synapse, STDP is observed as different profiles of Hebbian and anti-Hebbian learning rules. However, the specific roles of diverse STDP profiles in memory formation still remain elusive. Here, we show that the symmetry of the learning rate profile in STDP is crucial to determining the character of stored memory. Using computer simulations, we found that an asymmetric learning rate generates flexible memory that is volatile and easily overwritten by newly appended information. Moreover, a symmetric learning rate generates stable memory that can coexist with newly appended information. In addition, by combining these two conditions, we could realize a hybrid memory type that operates in a way intermediate between stable and flexible memory. Our results demonstrate that various attributes of memory functions may originate from differences in the synaptic stability. Nature Publishing Group UK 2017-07-18 /pmc/articles/PMC5516032/ /pubmed/28720795 http://dx.doi.org/10.1038/s41598-017-05929-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Park, Youngjin Choi, Woochul Paik, Se-Bum Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title | Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title_full | Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title_fullStr | Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title_full_unstemmed | Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title_short | Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
title_sort | symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516032/ https://www.ncbi.nlm.nih.gov/pubmed/28720795 http://dx.doi.org/10.1038/s41598-017-05929-2 |
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