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Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study

INTRODUCTION: The most common hereditary kidney condition is autosomal dominant polycystic kidney disease. It is the cause of 5–10% of end-stage renal disease. Its symptoms are generally late-onset, typically leading to development of hypertension and chronic kidney disease. Ultrasonography is the i...

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Autores principales: Strzelczyk, Marcin, Podgórski, Michał, Afshari, Susan, Tkaczyk, Marcin, Pawlak-Bratkowska, Monika, Grzelak, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Communications Sp. z o.o. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516076/
https://www.ncbi.nlm.nih.gov/pubmed/28856014
http://dx.doi.org/10.15557/JoU.2017.0011
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author Strzelczyk, Marcin
Podgórski, Michał
Afshari, Susan
Tkaczyk, Marcin
Pawlak-Bratkowska, Monika
Grzelak, Piotr
author_facet Strzelczyk, Marcin
Podgórski, Michał
Afshari, Susan
Tkaczyk, Marcin
Pawlak-Bratkowska, Monika
Grzelak, Piotr
author_sort Strzelczyk, Marcin
collection PubMed
description INTRODUCTION: The most common hereditary kidney condition is autosomal dominant polycystic kidney disease. It is the cause of 5–10% of end-stage renal disease. Its symptoms are generally late-onset, typically leading to development of hypertension and chronic kidney disease. Ultrasonography is the imaging modality of choice in its diagnosis and management. The aim of this study is to determine the diagnostic value of grayscale ultrasound imaging in evaluating disease severity. MATERIALS AND METHODS: The study group consisted of 81 patients diagnosed with autosomal dominant polycystic kidney disease, 35 adults and 46 children. Inclusion criterion for adults was the presence of at least 10 large cysts in each kidney; children included into the study had developed at least 1 large renal cyst in each kidney. The number of large cysts, echogenicity of kidney parenchyma, cortical thickness and presentation of cortex/medulla boundary were assessed with the use of Logiq E9 apparatus (GE Healthcare, Netherlands). Patients were divided into groups, based on these morphological parameters. Kidney function was assessed according to serum creatinine concentration and creatinine clearance. Statistical analysis was performed, with p-value lower than 0.05 considered as significant. RESULTS: The number of cysts and the degree of parenchymal dysfunction were the determinants of creatinine level and creatinine clearance, with the second predictor proving stronger. CONCLUSIONS: We recommend that an ultrasound kidney examination in patients with polycystic kidney disease should include evaluating renal parenchyma and the number of cysts for better assessment of disease severity.
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spelling pubmed-55160762017-08-30 Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study Strzelczyk, Marcin Podgórski, Michał Afshari, Susan Tkaczyk, Marcin Pawlak-Bratkowska, Monika Grzelak, Piotr J Ultrason Original Paper INTRODUCTION: The most common hereditary kidney condition is autosomal dominant polycystic kidney disease. It is the cause of 5–10% of end-stage renal disease. Its symptoms are generally late-onset, typically leading to development of hypertension and chronic kidney disease. Ultrasonography is the imaging modality of choice in its diagnosis and management. The aim of this study is to determine the diagnostic value of grayscale ultrasound imaging in evaluating disease severity. MATERIALS AND METHODS: The study group consisted of 81 patients diagnosed with autosomal dominant polycystic kidney disease, 35 adults and 46 children. Inclusion criterion for adults was the presence of at least 10 large cysts in each kidney; children included into the study had developed at least 1 large renal cyst in each kidney. The number of large cysts, echogenicity of kidney parenchyma, cortical thickness and presentation of cortex/medulla boundary were assessed with the use of Logiq E9 apparatus (GE Healthcare, Netherlands). Patients were divided into groups, based on these morphological parameters. Kidney function was assessed according to serum creatinine concentration and creatinine clearance. Statistical analysis was performed, with p-value lower than 0.05 considered as significant. RESULTS: The number of cysts and the degree of parenchymal dysfunction were the determinants of creatinine level and creatinine clearance, with the second predictor proving stronger. CONCLUSIONS: We recommend that an ultrasound kidney examination in patients with polycystic kidney disease should include evaluating renal parenchyma and the number of cysts for better assessment of disease severity. Medical Communications Sp. z o.o. 2017-06-30 2017-06 /pmc/articles/PMC5516076/ /pubmed/28856014 http://dx.doi.org/10.15557/JoU.2017.0011 Text en 2017 Polish Ultrasound Society. Published by Medical Communications Sp. z o.o. All rights reserved. http://creativecommons.org/licenses/by-nc-nd This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND). Reproduction is permitted for personal, educational, non-commercial use, provided that the original article is in whole, unmodified, and properly cited.
spellingShingle Original Paper
Strzelczyk, Marcin
Podgórski, Michał
Afshari, Susan
Tkaczyk, Marcin
Pawlak-Bratkowska, Monika
Grzelak, Piotr
Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title_full Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title_fullStr Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title_full_unstemmed Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title_short Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
title_sort grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516076/
https://www.ncbi.nlm.nih.gov/pubmed/28856014
http://dx.doi.org/10.15557/JoU.2017.0011
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