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Modulation of lipid biosynthesis by stress in diatoms

Diatoms are responsible for up to 40% of the carbon fixation in our oceans. The fixed carbon is moved through carbon metabolism towards the synthesis of organic molecules that are consumed through interlocking foodwebs, and this process is strongly impacted by the abiotic environment. However, it ha...

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Autores principales: Sayanova, Olga, Mimouni, Virginie, Ulmann, Lionel, Morant-Manceau, Annick, Pasquet, Virginie, Schoefs, Benoît, Napier, Johnathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516116/
https://www.ncbi.nlm.nih.gov/pubmed/28717017
http://dx.doi.org/10.1098/rstb.2016.0407
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author Sayanova, Olga
Mimouni, Virginie
Ulmann, Lionel
Morant-Manceau, Annick
Pasquet, Virginie
Schoefs, Benoît
Napier, Johnathan A.
author_facet Sayanova, Olga
Mimouni, Virginie
Ulmann, Lionel
Morant-Manceau, Annick
Pasquet, Virginie
Schoefs, Benoît
Napier, Johnathan A.
author_sort Sayanova, Olga
collection PubMed
description Diatoms are responsible for up to 40% of the carbon fixation in our oceans. The fixed carbon is moved through carbon metabolism towards the synthesis of organic molecules that are consumed through interlocking foodwebs, and this process is strongly impacted by the abiotic environment. However, it has become evident that diatoms can be used as ‘platform’ organisms for the production of high valuable bio-products such as lipids, pigments and carbohydrates where stress conditions can be used to direct carbon metabolism towards the commercial production of these compounds. In the first section of this review, some aspects of carbon metabolism in diatoms and how it is impacted by environmental factors are briefly described. The second section is focused on the biosynthesis of lipids and in particular omega-3 long-chain polyunsaturated fatty acids and how low temperature stress impacts on the production of these compounds. In a third section, we review the recent advances in bioengineering for lipid production. Finally, we discuss new perspectives for designing strains for the sustainable production of high-value lipids. This article is part of the themed issue ‘The peculiar carbon metabolism in diatoms’.
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spelling pubmed-55161162017-11-23 Modulation of lipid biosynthesis by stress in diatoms Sayanova, Olga Mimouni, Virginie Ulmann, Lionel Morant-Manceau, Annick Pasquet, Virginie Schoefs, Benoît Napier, Johnathan A. Philos Trans R Soc Lond B Biol Sci Articles Diatoms are responsible for up to 40% of the carbon fixation in our oceans. The fixed carbon is moved through carbon metabolism towards the synthesis of organic molecules that are consumed through interlocking foodwebs, and this process is strongly impacted by the abiotic environment. However, it has become evident that diatoms can be used as ‘platform’ organisms for the production of high valuable bio-products such as lipids, pigments and carbohydrates where stress conditions can be used to direct carbon metabolism towards the commercial production of these compounds. In the first section of this review, some aspects of carbon metabolism in diatoms and how it is impacted by environmental factors are briefly described. The second section is focused on the biosynthesis of lipids and in particular omega-3 long-chain polyunsaturated fatty acids and how low temperature stress impacts on the production of these compounds. In a third section, we review the recent advances in bioengineering for lipid production. Finally, we discuss new perspectives for designing strains for the sustainable production of high-value lipids. This article is part of the themed issue ‘The peculiar carbon metabolism in diatoms’. The Royal Society 2017-09-05 2017-07-17 /pmc/articles/PMC5516116/ /pubmed/28717017 http://dx.doi.org/10.1098/rstb.2016.0407 Text en © 2017 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Sayanova, Olga
Mimouni, Virginie
Ulmann, Lionel
Morant-Manceau, Annick
Pasquet, Virginie
Schoefs, Benoît
Napier, Johnathan A.
Modulation of lipid biosynthesis by stress in diatoms
title Modulation of lipid biosynthesis by stress in diatoms
title_full Modulation of lipid biosynthesis by stress in diatoms
title_fullStr Modulation of lipid biosynthesis by stress in diatoms
title_full_unstemmed Modulation of lipid biosynthesis by stress in diatoms
title_short Modulation of lipid biosynthesis by stress in diatoms
title_sort modulation of lipid biosynthesis by stress in diatoms
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516116/
https://www.ncbi.nlm.nih.gov/pubmed/28717017
http://dx.doi.org/10.1098/rstb.2016.0407
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