Cargando…

Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling

BACKGROUND: The physiological regulation of G protein-coupled receptors, through desensitization and internalization, modulates the length of the receptor signal and may influence the development of tolerance and dependence in response to chronic drug treatment. To explore the importance of receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scearce-Levie, Kimberly, Lieberman, Michael D, Elliott, Heather H, Conklin, Bruce R
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551613/ https://www.ncbi.nlm.nih.gov/pubmed/15707483 http://dx.doi.org/10.1186/1741-7007-3-3

Ejemplares similares

Internalization and desensitization of adenosine receptors
por: Klaasse, Elisabeth C., et al.
Publicado: (2007)

Characterization of Social Behaviors in caspase-3 deficient mice
por: Lo, Shih-Ching, et al.
Publicado: (2016)

Mineral Composition is Altered by Osteoblast Expression of an Engineered G(s)-Coupled Receptor
por: Kazakia, G. J., et al.
Publicado: (2011)

Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein–coupled receptors
por: Min, Xiao, et al.
Publicado: (2023)

Agonist-induced internalization and desensitization of the apelin receptor
por: Pope, George R., et al.
Publicado: (2016)

Rate of Homologous Desensitization and Internalization of the GLP-1 Receptor
por: Shaaban, Ghina, et al.
Publicado: (2016)

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor
por: Azevedo, Anthony W, et al.
Publicado: (2015)

Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization
por: Chaudhary, Preeti Kumari, et al.
Publicado: (2020)

COL25A1 triggers and promotes Alzheimer’s disease-like pathology in vivo
por: Tong, Ying, et al.
Publicado: (2009)

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2
por: Burström, Viktor, et al.
Publicado: (2023)

G(s) G Protein–Coupled Receptor Signaling in Osteoblasts Elicits Age-Dependent Effects on Bone Formation
por: Hsiao, Edward C, et al.
Publicado: (2010)

Engineering the Melanocortin-4 Receptor to Control Constitutive and Ligand-Mediated G(s) Signaling In Vivo
por: Srinivasan, Supriya, et al.
Publicado: (2007)

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor
por: Echeverría, Emiliana, et al.
Publicado: (2020)

C-Reactive Protein (CRP) Blocks the Desensitization of Agonistic Stimulated G Protein Coupled Receptors (GPCRs) in Neonatal Rat Cardiomyocytes
por: Wallukat, Gerd, et al.
Publicado: (2022)

Odorant Receptor Desensitization in Insects
por: Guo, Hao, et al.
Publicado: (2017)

Pathways for nicotinic receptor desensitization
por: Auerbach, Anthony
Publicado: (2020)

Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
por: Reiner, Andreas, et al.
Publicado: (2014)

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator
por: Bailes, Helena J., et al.
Publicado: (2017)

Engineering therapeutic antibodies targeting G-protein–coupled receptors
por: Jo, Migyeong, et al.
Publicado: (2016)

Ligand-Independent G Protein–Coupled Estrogen Receptor/G Protein–Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17β-Estradiol
por: Tutzauer, Julia, et al.
Publicado: (2021)

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
por: Berry, Michael H., et al.
Publicado: (2017)

G(i)-Coupled GPCR Signaling Controls the Formation and Organization of Human Pluripotent Colonies
por: Nakamura, Kenta, et al.
Publicado: (2009)

Structural mechanism of glutamate receptor activation and desensitization
por: Meyerson, Joel R., et al.
Publicado: (2014)

μ-Opioid receptor desensitization: homologous or heterologous?
por: Llorente, Javier, et al.
Publicado: (2012)

The desensitization gate of inhibitory Cys-loop receptors
por: Gielen, Marc, et al.
Publicado: (2015)

Mechanisms of differential desensitization of metabotropic glutamate receptors
por: Abreu, Nohely, et al.
Publicado: (2021)

Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes
por: Lengger, Bettina, et al.
Publicado: (2019)

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
por: Praveen, Praveen, et al.
Publicado: (2019)

Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies
por: Waltenspühl, Yann, et al.
Publicado: (2021)

Regulating G protein-coupled receptors by topological inversion
por: Denard, Bray, et al.
Publicado: (2019)

Astrocytic adenosine receptor A(2A) and G(s)-coupled signaling regulate memory
por: Orr, Anna G., et al.
Publicado: (2015)

Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
por: Carpenter, Byron, et al.
Publicado: (2016)

G Protein-coupled receptors: Multi-turnover GDP/GTP exchange catalysis on heterotrimeric G proteins
por: Ross, Elliott M
Publicado: (2014)

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
por: Höring, Carina, et al.
Publicado: (2021)

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
por: Martín‐Segura, Adrián, et al.
Publicado: (2019)

ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment
por: Sánchez-Fernández, Guzmán, et al.
Publicado: (2013)

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors
por: Renault, Pedro, et al.
Publicado: (2020)

Desensitizing interactions
por: LeBrasseur, Nicole
Publicado: (2002)

Desensitization in Tuberculosis
por: Willis, Henry Stuart
Publicado: (1943)

Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors
por: Nichols, Charles D., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_uoirjfqqo8mgf2qe1r2jcp62c3