mTOR signaling plays a critical role in the defects observed in muscle‐derived stem/progenitor cells isolated from a murine model of accelerated aging

Mice expressing reduced levels of ERCC1‐XPF (Ercc1 (−/Δ) mice) demonstrate premature onset of age‐related changes due to decreased repair of DNA damage. Muscle‐derived stem/progenitor cells (MDSPCs) isolated from Ercc1 (−/Δ) mice have an impaired capacity for cell differentiation. The mammalian targ...

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Detalles Bibliográficos
Autores principales: Takayama, Koji, Kawakami, Yohei, Lavasani, Mitra, Mu, Xiaodong, Cummins, James H., Yurube, Takashi, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516198/
https://www.ncbi.nlm.nih.gov/pubmed/27572850
http://dx.doi.org/10.1002/jor.23409

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