Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise...

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Detalles Bibliográficos
Autores principales: Fujii, Masayuki, Sato, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516356/
https://www.ncbi.nlm.nih.gov/pubmed/28720124
http://dx.doi.org/10.1186/s13073-017-0460-y
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author Fujii, Masayuki
Sato, Toshiro
author_facet Fujii, Masayuki
Sato, Toshiro
author_sort Fujii, Masayuki
collection PubMed
description Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5(+) intestinal stem cells, providing insights into their roles in homeostasis and cancer.
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spelling pubmed-55163562017-07-20 Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications Fujii, Masayuki Sato, Toshiro Genome Med Comment Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5(+) intestinal stem cells, providing insights into their roles in homeostasis and cancer. BioMed Central 2017-07-18 /pmc/articles/PMC5516356/ /pubmed/28720124 http://dx.doi.org/10.1186/s13073-017-0460-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Fujii, Masayuki
Sato, Toshiro
Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title_full Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title_fullStr Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title_full_unstemmed Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title_short Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
title_sort defining the role of lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516356/
https://www.ncbi.nlm.nih.gov/pubmed/28720124
http://dx.doi.org/10.1186/s13073-017-0460-y
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