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Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications
Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516356/ https://www.ncbi.nlm.nih.gov/pubmed/28720124 http://dx.doi.org/10.1186/s13073-017-0460-y |