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Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516683/ https://www.ncbi.nlm.nih.gov/pubmed/28716955 http://dx.doi.org/10.1101/lm.045195.117 |
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author | Bouchet, Courtney A. Lloyd, Brian A. Loetz, Esteban C. Farmer, Caroline E. Ostrovskyy, Mykola Haddad, Natalie Foright, Rebecca M. Greenwood, Benjamin N. |
author_facet | Bouchet, Courtney A. Lloyd, Brian A. Loetz, Esteban C. Farmer, Caroline E. Ostrovskyy, Mykola Haddad, Natalie Foright, Rebecca M. Greenwood, Benjamin N. |
author_sort | Bouchet, Courtney A. |
collection | PubMed |
description | Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced. |
format | Online Article Text |
id | pubmed-5516683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55166832018-08-01 Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner Bouchet, Courtney A. Lloyd, Brian A. Loetz, Esteban C. Farmer, Caroline E. Ostrovskyy, Mykola Haddad, Natalie Foright, Rebecca M. Greenwood, Benjamin N. Learn Mem Research Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced. Cold Spring Harbor Laboratory Press 2017-08 /pmc/articles/PMC5516683/ /pubmed/28716955 http://dx.doi.org/10.1101/lm.045195.117 Text en © 2017 Bouchet et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Bouchet, Courtney A. Lloyd, Brian A. Loetz, Esteban C. Farmer, Caroline E. Ostrovskyy, Mykola Haddad, Natalie Foright, Rebecca M. Greenwood, Benjamin N. Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title | Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title_full | Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title_fullStr | Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title_full_unstemmed | Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title_short | Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
title_sort | acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516683/ https://www.ncbi.nlm.nih.gov/pubmed/28716955 http://dx.doi.org/10.1101/lm.045195.117 |
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