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Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner

Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy...

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Autores principales: Bouchet, Courtney A., Lloyd, Brian A., Loetz, Esteban C., Farmer, Caroline E., Ostrovskyy, Mykola, Haddad, Natalie, Foright, Rebecca M., Greenwood, Benjamin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516683/
https://www.ncbi.nlm.nih.gov/pubmed/28716955
http://dx.doi.org/10.1101/lm.045195.117
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author Bouchet, Courtney A.
Lloyd, Brian A.
Loetz, Esteban C.
Farmer, Caroline E.
Ostrovskyy, Mykola
Haddad, Natalie
Foright, Rebecca M.
Greenwood, Benjamin N.
author_facet Bouchet, Courtney A.
Lloyd, Brian A.
Loetz, Esteban C.
Farmer, Caroline E.
Ostrovskyy, Mykola
Haddad, Natalie
Foright, Rebecca M.
Greenwood, Benjamin N.
author_sort Bouchet, Courtney A.
collection PubMed
description Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced.
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spelling pubmed-55166832018-08-01 Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner Bouchet, Courtney A. Lloyd, Brian A. Loetz, Esteban C. Farmer, Caroline E. Ostrovskyy, Mykola Haddad, Natalie Foright, Rebecca M. Greenwood, Benjamin N. Learn Mem Research Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced. Cold Spring Harbor Laboratory Press 2017-08 /pmc/articles/PMC5516683/ /pubmed/28716955 http://dx.doi.org/10.1101/lm.045195.117 Text en © 2017 Bouchet et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Bouchet, Courtney A.
Lloyd, Brian A.
Loetz, Esteban C.
Farmer, Caroline E.
Ostrovskyy, Mykola
Haddad, Natalie
Foright, Rebecca M.
Greenwood, Benjamin N.
Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title_full Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title_fullStr Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title_full_unstemmed Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title_short Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
title_sort acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516683/
https://www.ncbi.nlm.nih.gov/pubmed/28716955
http://dx.doi.org/10.1101/lm.045195.117
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