Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency

Cellular reprogramming is accompanied by a metabolic shift from oxidative phosphorylation (OXPHOS) toward glycolysis. Previous results from our laboratory showed that hypoxia alone is able to reprogram primordial germ cells (PGCs) into pluripotency and that this action is mediated by hypoxia-inducib...

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Detalles Bibliográficos
Autores principales: Sainz de la Maza, D., Moratilla, A., Aparicio, V., Lorca, C., Alcaina, Y., Martín, D., De Miguel, M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516724/
https://www.ncbi.nlm.nih.gov/pubmed/28757909
http://dx.doi.org/10.1155/2017/4745252

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