Cargando…

Lysosomes as Oxidative Targets for Cancer Therapy

Lysosomes are membrane-bound vesicles that contain hydrolases for the degradation and recycling of essential nutrients to maintain homeostasis within cells. Cancer cells have increased lysosomal function to proliferate, metabolize, and adapt to stressful environments. This has made cancer cells susc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dielschneider, Rebecca F., Henson, Elizabeth S., Gibson, Spencer B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516749/ https://www.ncbi.nlm.nih.gov/pubmed/28757908 http://dx.doi.org/10.1155/2017/3749157

Ejemplares similares

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells
por: Ma, Shumei, et al.
Publicado: (2017)

EGFR Family Members’ Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer
por: Henson, Elizabeth, et al.
Publicado: (2017)

Lysosomes as a Target of Anticancer Therapy
por: Trybus, Wojciech, et al.
Publicado: (2023)

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy
por: Postovit, Lynne, et al.
Publicado: (2018)

Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer
por: Henson, Elizabeth S, et al.
Publicado: (2007)

Lysosome-targeting agents in cancer therapy
por: Kroemer, Guido, et al.
Publicado: (2017)

Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells
por: Schacter, Jennifer L., et al.
Publicado: (2014)

Lysosomes as a therapeutic target
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

The Exploitation of Lysosomes in Cancer Therapy with Graphene-Based Nanomaterials
por: Ristic, Biljana, et al.
Publicado: (2023)

Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling
por: Dielschneider, R F, et al.
Publicado: (2014)

Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors
por: Garcia, Emily A., et al.
Publicado: (2022)

Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras
por: Seo, Jinho, et al.
Publicado: (2022)

Role of lysosomes in physiological activities, diseases, and therapy
por: Zhang, Ziqi, et al.
Publicado: (2021)

Lysosomes and Lysosomal Storage Diseases
por: Noebels, Jeffrey L.
Publicado: (1981)

Autophagy and the Lysosomal System in Cancer
por: Kumar, Suresh, et al.
Publicado: (2021)

Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics
por: Al‐Bari, Md. Abdul Alim
Publicado: (2020)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

Lysosomes and lysosome‐related organelles in immune responses
por: Watts, Colin
Publicado: (2022)

Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
por: Wang, Hongna, et al.
Publicado: (2023)

Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells
por: Chen, Yongqiang, et al.
Publicado: (2021)

CNS-Targeting Therapies for Lysosomal Storage Diseases: Current Advances and Challenges
por: Edelmann, Mariola J., et al.
Publicado: (2020)

Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease
por: Blumenreich, Shani, et al.
Publicado: (2020)

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain
por: Sims-Robinson, Catrina, et al.
Publicado: (2015)

Lysosomal Targeting with Stable and Sensitive Fluorescent Probes (Superior LysoProbes): Applications for Lysosome Labeling and Tracking during Apoptosis
por: Chen, Xin, et al.
Publicado: (2015)

Lysosomes in acute myeloid leukemia: potential therapeutic targets?
por: Rafiq, Sreoshee, et al.
Publicado: (2021)

Recent advances in gene therapy for lysosomal storage disorders
por: Rastall, David PW, et al.
Publicado: (2015)

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
por: Platt, Frances M., et al.
Publicado: (2012)

The role of lysosomes in cancer development and progression
por: Tang, Tao, et al.
Publicado: (2020)

Lysosomal Calcium Channels in Autophagy and Cancer
por: Wu, Yi, et al.
Publicado: (2021)

Lysosomes
por: Barrnett, Russell J.
Publicado: (1964)

Lysosomal Targeting of β‐Cyclodextrin
por: Mascherpa, Andrea, et al.
Publicado: (2022)

Proteasomal and lysosomal degradation for specific and durable suppression of immunotherapeutic targets
por: Wang, Yungang, et al.
Publicado: (2020)

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2021)

Gene Therapy for Lysosomal Storage Disorders: Ongoing Studies and Clinical Development
por: Massaro, Giulia, et al.
Publicado: (2021)

The Achilles’ heel of cancer: targeting tumors via lysosome-induced immunogenic cell death
por: Iulianna, Taritsa, et al.
Publicado: (2022)

An endogenous MDCK lysosomal membrane glycoprotein is targeted basolaterally before delivery to lysosomes
Publicado: (1991)

Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction
por: Wang, Han, et al.
Publicado: (2022)

Less Is More: Substrate Reduction Therapy for Lysosomal Storage Disorders
por: Coutinho, Maria Francisca, et al.
Publicado: (2016)

Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies
por: Banerji, Versha, et al.
Publicado: (2012)

Glucocerebrosidase: Functions in and Beyond the Lysosome
por: Boer, Daphne E.C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cucgenqb1sflftog5tplkbcf99