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Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population

BACKGROUND: Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione. Evidence suggests that genetic variations in the promoter region of genes coding a catalytic subunit (GCLC -129T/C) and a modifier subunit (GCLM -588C/T) of GCL have a functional impact on their transc...

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Detalles Bibliográficos
Autores principales:	Skvortsova, Liliya, Perfelyeva, Anastasia, Khussainova, Elmira, Mansharipova, Alma, Forman, Henry Jay, Djansugurova, Leyla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516751/ https://www.ncbi.nlm.nih.gov/pubmed/28757675 http://dx.doi.org/10.1155/2017/4209257

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