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Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology
BACKGROUND/OBJECTIVES: Targeted kinase inhibitors are an important class of agents in anticancer therapeutics, but their limited tolerability hampers their clinical performance. Identification of the molecular mechanisms underlying the development of adverse reactions will be helpful in establishing...
Autores principales: | Amemiya, Takahiro, Honma, Masashi, Kariya, Yoshiaki, Ghosh, Samik, Kitano, Hiroaki, Kurachi, Yoshihisa, Fujita, Ken-ichi, Sasaki, Yasutsuna, Homma, Yukio, Abernethy, Darrel R, Kume, Haruki, Suzuki, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516806/ https://www.ncbi.nlm.nih.gov/pubmed/28725458 http://dx.doi.org/10.1038/npjsba.2015.5 |
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