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Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology

BACKGROUND/OBJECTIVES: Targeted kinase inhibitors are an important class of agents in anticancer therapeutics, but their limited tolerability hampers their clinical performance. Identification of the molecular mechanisms underlying the development of adverse reactions will be helpful in establishing...

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Detalles Bibliográficos
Autores principales:	Amemiya, Takahiro, Honma, Masashi, Kariya, Yoshiaki, Ghosh, Samik, Kitano, Hiroaki, Kurachi, Yoshihisa, Fujita, Ken-ichi, Sasaki, Yasutsuna, Homma, Yukio, Abernethy, Darrel R, Kume, Haruki, Suzuki, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516806/ https://www.ncbi.nlm.nih.gov/pubmed/28725458 http://dx.doi.org/10.1038/npjsba.2015.5

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