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Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes

Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by cancer cells to leave the primary tumor site, invade surrounding tissue and establish distant metastases. A hallmark of EMT is the loss of E-cadherin expression, and one major signal for the induction of EMT is transfo...

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Detalles Bibliográficos
Autores principales:	Steinway, Steven Nathaniel, Zañudo, Jorge Gomez Tejeda, Michel, Paul J, Feith, David J, Loughran, Thomas P, Albert, Reka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516807/ https://www.ncbi.nlm.nih.gov/pubmed/28725463 http://dx.doi.org/10.1038/npjsba.2015.14

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