Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

BACKGROUND: Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases, including psoriasis. OBJECTIVE: The pr...

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Detalles Bibliográficos
Autores principales: Tarcha, Eric J., Olsen, Chelsea M., Probst, Peter, Peckham, David, Muñoz-Elías, Ernesto J., Kruger, James G., Iadonato, Shawn P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516987/
https://www.ncbi.nlm.nih.gov/pubmed/28723914
http://dx.doi.org/10.1371/journal.pone.0180762

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