Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection

HCV infection can decrease NAD(+)/NADH ratio, which could convert lipid metabolism to favor HCV replication. In hepatocytes, quinolinate phosphoribosyl transferase (QPRT) catabolizes quinolinic acid (QA) to nicotinic acid mononucleotide (NAMN) for de novo NAD synthesis. However, whether and how HCV...

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Detalles Bibliográficos
Autores principales: Wang, Zhilong, Gao, Yanhang, Zhang, Chao, Hu, Haiming, Guo, Dongwei, Xu, Yi, Xu, Qiuping, Zhang, Weihong, Deng, Sisi, Lv, Pingyun, Yang, Yan, Ding, Yanhua, Li, Qingquan, Weng, Changjiang, Chen, Xinwen, Gong, Sitang, Chen, Hairong, Niu, Junqi, Tang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517448/
https://www.ncbi.nlm.nih.gov/pubmed/28724915
http://dx.doi.org/10.1038/s41598-017-06254-4

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