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Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase

Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA primase. The N-terminal primase domain of the gene 4 protein of phage T7 comprises a zinc-binding domain that recognizes a specific DNA sequence and an RNA polymerase domain that catalyzes RNA polymerization. Based o...

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Detalles Bibliográficos
Autores principales:	Ilic, Stefan, Akabayov, Sabine R., Froimovici, Roy, Meiry, Ron, Vilenchik, Dan, Hernandez, Alfredo, Arthanari, Haribabu, Akabayov, Barak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517523/ https://www.ncbi.nlm.nih.gov/pubmed/28724886 http://dx.doi.org/10.1038/s41598-017-05534-3

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