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Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517524/ https://www.ncbi.nlm.nih.gov/pubmed/28725029 http://dx.doi.org/10.1038/s41598-017-06197-w |
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author | Mulla, Wesam Etzion, Sharon Elyagon, Sigal Gillis, Roni Murninkas, Michael Konstantino, Yuval Mannhardt, Ingra Eschenhagen, Thomas Liel-Cohen, Noah Etzion, Yoram |
author_facet | Mulla, Wesam Etzion, Sharon Elyagon, Sigal Gillis, Roni Murninkas, Michael Konstantino, Yuval Mannhardt, Ingra Eschenhagen, Thomas Liel-Cohen, Noah Etzion, Yoram |
author_sort | Mulla, Wesam |
collection | PubMed |
description | Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized. Electrodes were implanted either on the right atria (RA) and right ventricle (RV) or on the RV and LV. Following recovery, rats were either used for invasive hemodynamic measurements (pressure-volume analysis) or exposed to sustained RV vs. biventricular tachypacing for 3 days. RV pacing compromised, while LV-based pacing modes markedly enhanced cardiac performance. Changes in LV performance were associated with prominent compensatory changes in arterial resistance. Sustained RV tachypacing increased the electrocardiogram QTc interval by 7.9 ± 3.1 ms (n = 6, p < 0.05), dispersed refractoriness between the right and left pacing sites and induced important molecular changes mainly in the early-activated septal tissue. These effects were not observed during biventricular tachypacing (n = 6). Our results demonstrate that the rat is an attractive new model to study the biological consequences of LV dyssynchrony and resynchronization. |
format | Online Article Text |
id | pubmed-5517524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55175242017-07-20 Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats Mulla, Wesam Etzion, Sharon Elyagon, Sigal Gillis, Roni Murninkas, Michael Konstantino, Yuval Mannhardt, Ingra Eschenhagen, Thomas Liel-Cohen, Noah Etzion, Yoram Sci Rep Article Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized. Electrodes were implanted either on the right atria (RA) and right ventricle (RV) or on the RV and LV. Following recovery, rats were either used for invasive hemodynamic measurements (pressure-volume analysis) or exposed to sustained RV vs. biventricular tachypacing for 3 days. RV pacing compromised, while LV-based pacing modes markedly enhanced cardiac performance. Changes in LV performance were associated with prominent compensatory changes in arterial resistance. Sustained RV tachypacing increased the electrocardiogram QTc interval by 7.9 ± 3.1 ms (n = 6, p < 0.05), dispersed refractoriness between the right and left pacing sites and induced important molecular changes mainly in the early-activated septal tissue. These effects were not observed during biventricular tachypacing (n = 6). Our results demonstrate that the rat is an attractive new model to study the biological consequences of LV dyssynchrony and resynchronization. Nature Publishing Group UK 2017-07-19 /pmc/articles/PMC5517524/ /pubmed/28725029 http://dx.doi.org/10.1038/s41598-017-06197-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mulla, Wesam Etzion, Sharon Elyagon, Sigal Gillis, Roni Murninkas, Michael Konstantino, Yuval Mannhardt, Ingra Eschenhagen, Thomas Liel-Cohen, Noah Etzion, Yoram Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title | Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title_full | Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title_fullStr | Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title_full_unstemmed | Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title_short | Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
title_sort | prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517524/ https://www.ncbi.nlm.nih.gov/pubmed/28725029 http://dx.doi.org/10.1038/s41598-017-06197-w |
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