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Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches

Previously, we demonstrated production of an active recombinant human N-acetylgalactosamine-6-sulfatase (rhGALNS) enzyme in Escherichia coli as a potential therapeutic alternative for mucopolysaccharidosis IVA. However, most of the rhGALNS produced was present as protein aggregates. Here, several me...

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Detalles Bibliográficos
Autores principales:	Reyes, Luis H., Cardona, Carolina, Pimentel, Luisa, Rodríguez-López, Alexander, Alméciga-Díaz, Carlos J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517531/ https://www.ncbi.nlm.nih.gov/pubmed/28724898 http://dx.doi.org/10.1038/s41598-017-06367-w

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