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Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)

Aim: To investigate the association of retinal vascular changes with a risk of dementia in longitudinal population-based study. Methods: We performed a nested case-control study of 3,718 persons, aged 40–89 years, enrolled between 1983 and 2004. Retinal vascular changes were observed in 351 cases wi...

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Autores principales: Jinnouchi, Hiroshige, Kitamura, Akihiko, Yamagishi, Kazumasa, Kiyama, Masahiko, Imano, Hironori, Okada, Takeo, Cui, Renzhe, Umesawa, Mitsumasa, Muraki, Isao, Hayama-Terada, Mina, Kawasaki, Ryo, Sankai, Tomoko, Ohira, Tetsuya, Iso, Hiroyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517542/
https://www.ncbi.nlm.nih.gov/pubmed/27904027
http://dx.doi.org/10.5551/jat.37291
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author Jinnouchi, Hiroshige
Kitamura, Akihiko
Yamagishi, Kazumasa
Kiyama, Masahiko
Imano, Hironori
Okada, Takeo
Cui, Renzhe
Umesawa, Mitsumasa
Muraki, Isao
Hayama-Terada, Mina
Kawasaki, Ryo
Sankai, Tomoko
Ohira, Tetsuya
Iso, Hiroyasu
author_facet Jinnouchi, Hiroshige
Kitamura, Akihiko
Yamagishi, Kazumasa
Kiyama, Masahiko
Imano, Hironori
Okada, Takeo
Cui, Renzhe
Umesawa, Mitsumasa
Muraki, Isao
Hayama-Terada, Mina
Kawasaki, Ryo
Sankai, Tomoko
Ohira, Tetsuya
Iso, Hiroyasu
author_sort Jinnouchi, Hiroshige
collection PubMed
description Aim: To investigate the association of retinal vascular changes with a risk of dementia in longitudinal population-based study. Methods: We performed a nested case-control study of 3,718 persons, aged 40–89 years, enrolled between 1983 and 2004. Retinal vascular changes were observed in 351 cases with disabling dementia (average period before the onset, 11.2 years) and in 702 controls matched for sex, age, and baseline year. Incidence of disabling dementia was defined as individuals who received cares for disabilities including dementia-related symptoms and/or behavioral disturbance. Conditional logistic regression analysis was used to calculate odds ratio (OR) and multivariable adjusted OR (Models 1 and 2) for incidence of disabling dementia according to each retinal vascular change. Regarding confounding variables, Model 1 included overweight status, hypertension, hyperglycemia, dyslipidemia, and smoking status, whereas Model 2 also included incidence of stroke prior to disabling dementia for further analysis. Results: The proportion of cases (controls) with retinal vascular changes was 23.1 (15.7)% for generalized arteriolar narrowing, 7.7 (7.5)% for focal arteriolar narrowing, 15.7 (11.8)% for arteriovenous nicking, 10.5 (9.3)% for increased arteriolar wall reflex, and 11.4 (9.8)% for any other retinopathy. Generalized arteriolar narrowing was associated with an increased risk of disabling dementia: crude OR, 1.66 (95% confidence interval, 1.19–2.31); Model 1: OR, 1.58 (1.12–2.23); Model 2: OR, 1.48 (1.04–2.10). The number of retinal abnormalities was associated in a dose–response manner with the risk. Conclusion: Generalized arteriolar narrowing and total number of retinal abnormalities may be useful markers for identifying persons at higher risks of disabling dementia.
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spelling pubmed-55175422017-07-21 Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS) Jinnouchi, Hiroshige Kitamura, Akihiko Yamagishi, Kazumasa Kiyama, Masahiko Imano, Hironori Okada, Takeo Cui, Renzhe Umesawa, Mitsumasa Muraki, Isao Hayama-Terada, Mina Kawasaki, Ryo Sankai, Tomoko Ohira, Tetsuya Iso, Hiroyasu J Atheroscler Thromb Original Article Aim: To investigate the association of retinal vascular changes with a risk of dementia in longitudinal population-based study. Methods: We performed a nested case-control study of 3,718 persons, aged 40–89 years, enrolled between 1983 and 2004. Retinal vascular changes were observed in 351 cases with disabling dementia (average period before the onset, 11.2 years) and in 702 controls matched for sex, age, and baseline year. Incidence of disabling dementia was defined as individuals who received cares for disabilities including dementia-related symptoms and/or behavioral disturbance. Conditional logistic regression analysis was used to calculate odds ratio (OR) and multivariable adjusted OR (Models 1 and 2) for incidence of disabling dementia according to each retinal vascular change. Regarding confounding variables, Model 1 included overweight status, hypertension, hyperglycemia, dyslipidemia, and smoking status, whereas Model 2 also included incidence of stroke prior to disabling dementia for further analysis. Results: The proportion of cases (controls) with retinal vascular changes was 23.1 (15.7)% for generalized arteriolar narrowing, 7.7 (7.5)% for focal arteriolar narrowing, 15.7 (11.8)% for arteriovenous nicking, 10.5 (9.3)% for increased arteriolar wall reflex, and 11.4 (9.8)% for any other retinopathy. Generalized arteriolar narrowing was associated with an increased risk of disabling dementia: crude OR, 1.66 (95% confidence interval, 1.19–2.31); Model 1: OR, 1.58 (1.12–2.23); Model 2: OR, 1.48 (1.04–2.10). The number of retinal abnormalities was associated in a dose–response manner with the risk. Conclusion: Generalized arteriolar narrowing and total number of retinal abnormalities may be useful markers for identifying persons at higher risks of disabling dementia. Japan Atherosclerosis Society 2017-07-01 /pmc/articles/PMC5517542/ /pubmed/27904027 http://dx.doi.org/10.5551/jat.37291 Text en 2017 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Jinnouchi, Hiroshige
Kitamura, Akihiko
Yamagishi, Kazumasa
Kiyama, Masahiko
Imano, Hironori
Okada, Takeo
Cui, Renzhe
Umesawa, Mitsumasa
Muraki, Isao
Hayama-Terada, Mina
Kawasaki, Ryo
Sankai, Tomoko
Ohira, Tetsuya
Iso, Hiroyasu
Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title_full Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title_fullStr Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title_full_unstemmed Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title_short Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)
title_sort retinal vascular changes and prospective risk of disabling dementia: the circulatory risk in communities study (circs)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517542/
https://www.ncbi.nlm.nih.gov/pubmed/27904027
http://dx.doi.org/10.5551/jat.37291
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