Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling

Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infectio...

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Autores principales: He, Meina, Su, Dan, Liu, Qinghong, Gao, Wenjuan, Kang, Youmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517594/
https://www.ncbi.nlm.nih.gov/pubmed/28724955
http://dx.doi.org/10.1038/s41598-017-06261-5
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author He, Meina
Su, Dan
Liu, Qinghong
Gao, Wenjuan
Kang, Youmin
author_facet He, Meina
Su, Dan
Liu, Qinghong
Gao, Wenjuan
Kang, Youmin
author_sort He, Meina
collection PubMed
description Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance.
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spelling pubmed-55175942017-07-20 Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling He, Meina Su, Dan Liu, Qinghong Gao, Wenjuan Kang, Youmin Sci Rep Article Currently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance. Nature Publishing Group UK 2017-07-19 /pmc/articles/PMC5517594/ /pubmed/28724955 http://dx.doi.org/10.1038/s41598-017-06261-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
He, Meina
Su, Dan
Liu, Qinghong
Gao, Wenjuan
Kang, Youmin
Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_full Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_fullStr Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_full_unstemmed Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_short Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling
title_sort mushroom lectin overcomes hepatitis b virus tolerance via tlr6 signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517594/
https://www.ncbi.nlm.nih.gov/pubmed/28724955
http://dx.doi.org/10.1038/s41598-017-06261-5
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