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Dynamics of high viscosity contrast confluent microfluidic flows
The laminar nature of microfluidic flows is most elegantly demonstrated via the confluence of two fluids forming two stable parallel flows within a single channel meeting at a highly stable interface. However, maintenance of laminar conditions can become complicated when there is a large viscosity c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517621/ https://www.ncbi.nlm.nih.gov/pubmed/28724996 http://dx.doi.org/10.1038/s41598-017-06260-6 |
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author | Kurdzinski, Michael E. Gol, Berrak Hee, Aaron Co Thurgood, Peter Zhu, Jiu Yang Petersen, Phred Mitchell, Arnan Khoshmanesh, Khashayar |
author_facet | Kurdzinski, Michael E. Gol, Berrak Hee, Aaron Co Thurgood, Peter Zhu, Jiu Yang Petersen, Phred Mitchell, Arnan Khoshmanesh, Khashayar |
author_sort | Kurdzinski, Michael E. |
collection | PubMed |
description | The laminar nature of microfluidic flows is most elegantly demonstrated via the confluence of two fluids forming two stable parallel flows within a single channel meeting at a highly stable interface. However, maintenance of laminar conditions can become complicated when there is a large viscosity contrast between the neighbouring flows leading to unique instability patterns along their interface. Here, we study the dynamics of high viscosity contrast confluent flows – specifically a core flow made of highly viscous glycerol confined by sheath flows made of water within a microfluidic flow focusing system. Our experiments indicate the formation of tapered core structures along the middle of the channel. Increasing the sheath flow rate shortens the tapered core, and importantly induces local instability patterns along the interface of core-sheath flows. The dynamics of such tapered core structures is governed by the intensity of instability patterns and the length of the core, according to which the core structure can experience stable, disturbed, broken or oscillated regimes. We have studied the dynamics of tapered core structures under these regimes. In particular, we have analysed the amplitude and frequency of core displacements during the broken core and oscillating core regimes, which have not been investigated before. |
format | Online Article Text |
id | pubmed-5517621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55176212017-07-20 Dynamics of high viscosity contrast confluent microfluidic flows Kurdzinski, Michael E. Gol, Berrak Hee, Aaron Co Thurgood, Peter Zhu, Jiu Yang Petersen, Phred Mitchell, Arnan Khoshmanesh, Khashayar Sci Rep Article The laminar nature of microfluidic flows is most elegantly demonstrated via the confluence of two fluids forming two stable parallel flows within a single channel meeting at a highly stable interface. However, maintenance of laminar conditions can become complicated when there is a large viscosity contrast between the neighbouring flows leading to unique instability patterns along their interface. Here, we study the dynamics of high viscosity contrast confluent flows – specifically a core flow made of highly viscous glycerol confined by sheath flows made of water within a microfluidic flow focusing system. Our experiments indicate the formation of tapered core structures along the middle of the channel. Increasing the sheath flow rate shortens the tapered core, and importantly induces local instability patterns along the interface of core-sheath flows. The dynamics of such tapered core structures is governed by the intensity of instability patterns and the length of the core, according to which the core structure can experience stable, disturbed, broken or oscillated regimes. We have studied the dynamics of tapered core structures under these regimes. In particular, we have analysed the amplitude and frequency of core displacements during the broken core and oscillating core regimes, which have not been investigated before. Nature Publishing Group UK 2017-07-19 /pmc/articles/PMC5517621/ /pubmed/28724996 http://dx.doi.org/10.1038/s41598-017-06260-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kurdzinski, Michael E. Gol, Berrak Hee, Aaron Co Thurgood, Peter Zhu, Jiu Yang Petersen, Phred Mitchell, Arnan Khoshmanesh, Khashayar Dynamics of high viscosity contrast confluent microfluidic flows |
title | Dynamics of high viscosity contrast confluent microfluidic flows |
title_full | Dynamics of high viscosity contrast confluent microfluidic flows |
title_fullStr | Dynamics of high viscosity contrast confluent microfluidic flows |
title_full_unstemmed | Dynamics of high viscosity contrast confluent microfluidic flows |
title_short | Dynamics of high viscosity contrast confluent microfluidic flows |
title_sort | dynamics of high viscosity contrast confluent microfluidic flows |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517621/ https://www.ncbi.nlm.nih.gov/pubmed/28724996 http://dx.doi.org/10.1038/s41598-017-06260-6 |
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