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Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae
The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed. Cross-seeding, where one aggregated protein templates the misfolding of a heterologous protein, is one mechanism proposed to s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517628/ https://www.ncbi.nlm.nih.gov/pubmed/28724957 http://dx.doi.org/10.1038/s41598-017-05829-5 |