Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities

Single domain antibodies (sdAbs), made of natural single variable regions of camelid or cartilaginous fish antibodies, or unpaired variable regions of mouse or human IgGs, are some of the more promising biologic modalities. However, such conventional sdAbs have difficulties of either using unwieldy...

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Detalles Bibliográficos
Autores principales: Shinozaki, Naoya, Hashimoto, Ryuji, Fukui, Kiichi, Uchiyama, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517631/
https://www.ncbi.nlm.nih.gov/pubmed/28725057
http://dx.doi.org/10.1038/s41598-017-06277-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517631/
https://www.ncbi.nlm.nih.gov/pubmed/28725057
http://dx.doi.org/10.1038/s41598-017-06277-x

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