Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth

Honokiol (HNK) is a small molecule with potent anti-inflammatory and anti-tumorigenic properties; yet the molecular targets of HNK are not well studied. Hyperactivation of the receptor tyrosine kinase c-Met and overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role...

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Detalles Bibliográficos
Autores principales: Balan, Murugabaskar, Chakraborty, Samik, Flynn, Evelyn, Zurakowski, David, Pal, Soumitro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517643/
https://www.ncbi.nlm.nih.gov/pubmed/28724911
http://dx.doi.org/10.1038/s41598-017-05455-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517643/
https://www.ncbi.nlm.nih.gov/pubmed/28724911
http://dx.doi.org/10.1038/s41598-017-05455-1

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