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Tamoxifen reverses epithelial–mesenchymal transition by demethylating miR-200c in triple-negative breast cancer cells

BACKGROUND: Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM also possesses ER-independent antitumor activity through an unclear mechanism. The...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Cheng, Yu, Wang, Yan, Fan, Yibo, Li, Ce, Zhang, Ye, Wang, Yiding, Dong, Qian, Ma, Yanju, Teng, Yue-e, Qu, Xiujuan, Liu, Yunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518097/
https://www.ncbi.nlm.nih.gov/pubmed/28724364
http://dx.doi.org/10.1186/s12885-017-3457-4