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Model‐Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion

Investigation of the cardiovascular proarrhythmic potential of a new chemical entity is now an integral part of drug development. Studies suggest that meals and glycemic changes can influence QT intervals, and a semimechanistic model has been developed that incorporates the effects of changes in glu...

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Detalles Bibliográficos
Autores principales:	Cirincione, Brenda, LaCreta, Frank, Sager, Philip, Mager, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Drug Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518197/ https://www.ncbi.nlm.nih.gov/pubmed/28543393 http://dx.doi.org/10.1002/jcph.882

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