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Inconsistency Between Univariate and Multiple Logistic Regressions
Logistic regression is a popular statistical method in studying the effects of covariates on binary outcomes. It has been widely used in both clinical trials and observational studies. However, the results from the univariate regression and from the multiple logistic regression tend to be conflictin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shanghai Municipal Bureau of Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518262/ https://www.ncbi.nlm.nih.gov/pubmed/28765686 http://dx.doi.org/10.11919/j.issn.1002-0829.217031 |
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author | WANG, Hongyue PENG, Jing WANG, Bokai LU, Xiang ZHENG, Julia Z. WANG, Kejia TU, Xin M. FENG, Changyong |
author_facet | WANG, Hongyue PENG, Jing WANG, Bokai LU, Xiang ZHENG, Julia Z. WANG, Kejia TU, Xin M. FENG, Changyong |
author_sort | WANG, Hongyue |
collection | PubMed |
description | Logistic regression is a popular statistical method in studying the effects of covariates on binary outcomes. It has been widely used in both clinical trials and observational studies. However, the results from the univariate regression and from the multiple logistic regression tend to be conflicting. A covariate may show very strong effect on the outcome in the multiple regression but not in the univariate regression, and vice versa. These facts have not been well appreciated in biomedical research. Misuse of logistic regression is very prevalent in medical publications. In this paper, we study the inconsistency between the univariate and multiple logistic regressions and give advice in the model section in multiple logistic regression analysis. |
format | Online Article Text |
id | pubmed-5518262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shanghai Municipal Bureau of Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-55182622017-08-01 Inconsistency Between Univariate and Multiple Logistic Regressions WANG, Hongyue PENG, Jing WANG, Bokai LU, Xiang ZHENG, Julia Z. WANG, Kejia TU, Xin M. FENG, Changyong Shanghai Arch Psychiatry Biostatistics in Psychiatry (38) Logistic regression is a popular statistical method in studying the effects of covariates on binary outcomes. It has been widely used in both clinical trials and observational studies. However, the results from the univariate regression and from the multiple logistic regression tend to be conflicting. A covariate may show very strong effect on the outcome in the multiple regression but not in the univariate regression, and vice versa. These facts have not been well appreciated in biomedical research. Misuse of logistic regression is very prevalent in medical publications. In this paper, we study the inconsistency between the univariate and multiple logistic regressions and give advice in the model section in multiple logistic regression analysis. Shanghai Municipal Bureau of Publishing 2017-04-25 2017-04-25 /pmc/articles/PMC5518262/ /pubmed/28765686 http://dx.doi.org/10.11919/j.issn.1002-0829.217031 Text en © Shanghai Municipal Bureau of Publishing http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Biostatistics in Psychiatry (38) WANG, Hongyue PENG, Jing WANG, Bokai LU, Xiang ZHENG, Julia Z. WANG, Kejia TU, Xin M. FENG, Changyong Inconsistency Between Univariate and Multiple Logistic Regressions |
title | Inconsistency Between Univariate and Multiple Logistic Regressions |
title_full | Inconsistency Between Univariate and Multiple Logistic Regressions |
title_fullStr | Inconsistency Between Univariate and Multiple Logistic Regressions |
title_full_unstemmed | Inconsistency Between Univariate and Multiple Logistic Regressions |
title_short | Inconsistency Between Univariate and Multiple Logistic Regressions |
title_sort | inconsistency between univariate and multiple logistic regressions |
topic | Biostatistics in Psychiatry (38) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518262/ https://www.ncbi.nlm.nih.gov/pubmed/28765686 http://dx.doi.org/10.11919/j.issn.1002-0829.217031 |
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