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Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis

[Image: see text] During catalysis by liver alcohol dehydrogenase (ADH), a water bound to the catalytic zinc is replaced by the oxygen of the substrates. The mechanism might involve a pentacoordinated zinc or a double-displacement reaction with participation by a nearby glutamate residue, as suggest...

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Detalles Bibliográficos
Autores principales: Plapp, Bryce V., Savarimuthu, Baskar Raj, Ferraro, Daniel J., Rubach, Jon K., Brown, Eric N., Ramaswamy, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518280/
https://www.ncbi.nlm.nih.gov/pubmed/28640600
http://dx.doi.org/10.1021/acs.biochem.7b00446

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