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Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution
The evolution of resistance against pesticides is an important problem of modern agriculture. The high‐dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518302/ https://www.ncbi.nlm.nih.gov/pubmed/28422284 http://dx.doi.org/10.1111/evo.13255 |
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author | Takahashi, Daisuke Yamanaka, Takehiko Sudo, Masaaki Andow, David A. |
author_facet | Takahashi, Daisuke Yamanaka, Takehiko Sudo, Masaaki Andow, David A. |
author_sort | Takahashi, Daisuke |
collection | PubMed |
description | The evolution of resistance against pesticides is an important problem of modern agriculture. The high‐dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two‐patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source‐sink environments. |
format | Online Article Text |
id | pubmed-5518302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55183022017-08-03 Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution Takahashi, Daisuke Yamanaka, Takehiko Sudo, Masaaki Andow, David A. Evolution Original Articles The evolution of resistance against pesticides is an important problem of modern agriculture. The high‐dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two‐patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source‐sink environments. John Wiley and Sons Inc. 2017-05-04 2017-06 /pmc/articles/PMC5518302/ /pubmed/28422284 http://dx.doi.org/10.1111/evo.13255 Text en © 2017 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Takahashi, Daisuke Yamanaka, Takehiko Sudo, Masaaki Andow, David A. Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title | Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title_full | Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title_fullStr | Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title_full_unstemmed | Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title_short | Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution |
title_sort | is a larger refuge always better? dispersal and dose in pesticide resistance evolution |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518302/ https://www.ncbi.nlm.nih.gov/pubmed/28422284 http://dx.doi.org/10.1111/evo.13255 |
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