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Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer

The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already constitute approved targets in cancer therapy...

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Detalles Bibliográficos
Autores principales:	Granier, Clemence, De Guillebon, Eleonore, Blanc, Charlotte, Roussel, Helene, Badoual, Cecile, Colin, Elia, Saldmann, Antonin, Gey, Alain, Oudard, Stephane, Tartour, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518304/ https://www.ncbi.nlm.nih.gov/pubmed/28761757 http://dx.doi.org/10.1136/esmoopen-2017-000213

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