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Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for t...

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Detalles Bibliográficos
Autores principales: Lv, Jingzhu, Xu, Tao, Qian, Zhongqing, Wang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518512/
https://www.ncbi.nlm.nih.gov/pubmed/28761441
http://dx.doi.org/10.1155/2017/7150386
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author Lv, Jingzhu
Xu, Tao
Qian, Zhongqing
Wang, Hongtao
author_facet Lv, Jingzhu
Xu, Tao
Qian, Zhongqing
Wang, Hongtao
author_sort Lv, Jingzhu
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.
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spelling pubmed-55185122017-07-31 Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma Lv, Jingzhu Xu, Tao Qian, Zhongqing Wang, Hongtao Gastroenterol Res Pract Review Article Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required. Hindawi 2017 2017-07-06 /pmc/articles/PMC5518512/ /pubmed/28761441 http://dx.doi.org/10.1155/2017/7150386 Text en Copyright © 2017 Jingzhu Lv et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lv, Jingzhu
Xu, Tao
Qian, Zhongqing
Wang, Hongtao
Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title_full Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title_fullStr Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title_full_unstemmed Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title_short Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
title_sort association between hla-dq gene polymorphisms and hbv-related hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518512/
https://www.ncbi.nlm.nih.gov/pubmed/28761441
http://dx.doi.org/10.1155/2017/7150386
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