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Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518512/ https://www.ncbi.nlm.nih.gov/pubmed/28761441 http://dx.doi.org/10.1155/2017/7150386 |
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author | Lv, Jingzhu Xu, Tao Qian, Zhongqing Wang, Hongtao |
author_facet | Lv, Jingzhu Xu, Tao Qian, Zhongqing Wang, Hongtao |
author_sort | Lv, Jingzhu |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required. |
format | Online Article Text |
id | pubmed-5518512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55185122017-07-31 Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma Lv, Jingzhu Xu, Tao Qian, Zhongqing Wang, Hongtao Gastroenterol Res Pract Review Article Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required. Hindawi 2017 2017-07-06 /pmc/articles/PMC5518512/ /pubmed/28761441 http://dx.doi.org/10.1155/2017/7150386 Text en Copyright © 2017 Jingzhu Lv et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lv, Jingzhu Xu, Tao Qian, Zhongqing Wang, Hongtao Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title_full | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title_fullStr | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title_full_unstemmed | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title_short | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
title_sort | association between hla-dq gene polymorphisms and hbv-related hepatocellular carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518512/ https://www.ncbi.nlm.nih.gov/pubmed/28761441 http://dx.doi.org/10.1155/2017/7150386 |
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