A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the β-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. It has proved effective in in v...

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Detalles Bibliográficos
Autores principales: Tao, W., Yurkovich, M. E., Wen, S., Lebe, K. E., Samborskyy, M., Liu, Y., Yang, A., Ju, Y., Deng, Z., Tosin, M., Sun, Y., Leadlay, P. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518548/
https://www.ncbi.nlm.nih.gov/pubmed/28791099
http://dx.doi.org/10.1039/c5sc03059e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518548/
https://www.ncbi.nlm.nih.gov/pubmed/28791099
http://dx.doi.org/10.1039/c5sc03059e

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