Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation

Ubiquitin linkage to cysteine is an unconventional modification targeting protein for degradation. However, the physiological regulation of cysteine ubiquitination is still mysterious. Here we found that ACAT2, a cellular enzyme converting cholesterol and fatty acid to cholesteryl esters, was ubiqui...

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Detalles Bibliográficos
Autores principales: Wang, Yong-Jian, Bian, Yan, Luo, Jie, Lu, Ming, Xiong, Ying, Guo, Shu-Yuan, Yin, Hui-Yong, Lin, Xu, Li, Qin, Chang, Catherine CY, Chang, Ta-Yuan, Li, Bo-Liang, Song, Bao-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518634/
https://www.ncbi.nlm.nih.gov/pubmed/28604676
http://dx.doi.org/10.1038/ncb3551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518634/
https://www.ncbi.nlm.nih.gov/pubmed/28604676
http://dx.doi.org/10.1038/ncb3551

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