Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α(1D)-adrenoceptor antagonists

Chiral drug naftopidil (NAF), a specific α(1D)-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α(1D)-AR, but the binding mechanism o...

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Detalles Bibliográficos
Autores principales: Xu, Wei, Huang, Junjun, Jiang, Renwang, Yuan, Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518653/
https://www.ncbi.nlm.nih.gov/pubmed/28752036
http://dx.doi.org/10.1016/j.apsb.2017.04.011

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