Deacetylation of mycothiol-derived ‘waste product’ triggers the last biosynthetic steps of lincosamide antibiotics

The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the mycothiol-dependent detoxification system of actinomycetes. This machinery provides the last proven lincomycin intermediate, a mercapturic acid derivative, which formally represents the ‘waste product’ of the det...

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Detalles Bibliográficos
Autores principales: Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518657/
https://www.ncbi.nlm.nih.gov/pubmed/28791100
http://dx.doi.org/10.1039/c5sc03327f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518657/
https://www.ncbi.nlm.nih.gov/pubmed/28791100
http://dx.doi.org/10.1039/c5sc03327f

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