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The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations

OBJECTIVES: We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS: We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic po...

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Autores principales: Wang, T, Ma, X, Tang, T, Higuchi, K, Peng, D, Zhang, R, Chen, M, Yan, J, Wang, S, Yan, D, He, Z, Jiang, F, Bao, Y, Jia, W, Ishida, K, Hu, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518809/
https://www.ncbi.nlm.nih.gov/pubmed/28530680
http://dx.doi.org/10.1038/nutd.2017.28
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author Wang, T
Ma, X
Tang, T
Higuchi, K
Peng, D
Zhang, R
Chen, M
Yan, J
Wang, S
Yan, D
He, Z
Jiang, F
Bao, Y
Jia, W
Ishida, K
Hu, C
author_facet Wang, T
Ma, X
Tang, T
Higuchi, K
Peng, D
Zhang, R
Chen, M
Yan, J
Wang, S
Yan, D
He, Z
Jiang, F
Bao, Y
Jia, W
Ishida, K
Hu, C
author_sort Wang, T
collection PubMed
description OBJECTIVES: We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS: We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (GIPR) among 2884 community-based individuals from Han Chinese populations. Linear analysis was applied to test the associations of these variants with visceral fat area (VFA) and subcutaneous fat area (SFA) quantified by magnetic resonance imaging as well as glucose-related traits. RESULTS: We found that the C allele of rs4794008 of GIP tended to increase the VFA and the VFA/SFA ratio in all subjects (P=0.050 and P=0.054, respectively), and rs4794008 was associated with the VFA/SFA ratio in males (P=0.041) after adjusting for the BMI. The VFA-increasing allele of rs4794008 was not related to any glucose metabolism traits. However, rs9904288 of GIP was associated with the SFA in males as well as glucose-related traits in all subjects (P range, 0.004–0.049), and the GIPR variants displayed associations with both fat- and glucose-related traits. CONCLUSIONS: The results could provide the evidence that GIP might modulate visceral fat accumulation via incretin function or independent of incretin.
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spelling pubmed-55188092017-07-24 The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations Wang, T Ma, X Tang, T Higuchi, K Peng, D Zhang, R Chen, M Yan, J Wang, S Yan, D He, Z Jiang, F Bao, Y Jia, W Ishida, K Hu, C Nutr Diabetes Original Article OBJECTIVES: We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations. METHODS: We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (GIPR) among 2884 community-based individuals from Han Chinese populations. Linear analysis was applied to test the associations of these variants with visceral fat area (VFA) and subcutaneous fat area (SFA) quantified by magnetic resonance imaging as well as glucose-related traits. RESULTS: We found that the C allele of rs4794008 of GIP tended to increase the VFA and the VFA/SFA ratio in all subjects (P=0.050 and P=0.054, respectively), and rs4794008 was associated with the VFA/SFA ratio in males (P=0.041) after adjusting for the BMI. The VFA-increasing allele of rs4794008 was not related to any glucose metabolism traits. However, rs9904288 of GIP was associated with the SFA in males as well as glucose-related traits in all subjects (P range, 0.004–0.049), and the GIPR variants displayed associations with both fat- and glucose-related traits. CONCLUSIONS: The results could provide the evidence that GIP might modulate visceral fat accumulation via incretin function or independent of incretin. Nature Publishing Group 2017-05 2017-05-22 /pmc/articles/PMC5518809/ /pubmed/28530680 http://dx.doi.org/10.1038/nutd.2017.28 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Wang, T
Ma, X
Tang, T
Higuchi, K
Peng, D
Zhang, R
Chen, M
Yan, J
Wang, S
Yan, D
He, Z
Jiang, F
Bao, Y
Jia, W
Ishida, K
Hu, C
The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title_full The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title_fullStr The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title_full_unstemmed The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title_short The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
title_sort effect of glucose-dependent insulinotropic polypeptide (gip) variants on visceral fat accumulation in han chinese populations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518809/
https://www.ncbi.nlm.nih.gov/pubmed/28530680
http://dx.doi.org/10.1038/nutd.2017.28
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