Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells

DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can drive tumor growth irrespective of their effects on genomic stability. We discover a m...

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Detalles Bibliográficos
Autores principales: Liu, Xinjian, Li, Fang, Huang, Qian, Zhang, Zhengxiang, Zhou, Ling, Deng, Yu, Zhou, Min, Fleenor, Donald E, Wang, He, Kastan, Michael B, Li, Chuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518870/
https://www.ncbi.nlm.nih.gov/pubmed/28337983
http://dx.doi.org/10.1038/cr.2017.41

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